Ypsilanti (pronounced /ˌɪpsɨˈlænti/ us dict: ĭp′·sĭ·lăn′·tē, commonly shortened to Ypsi, but often mispronounced /ˌjɪpsɨˈlænti/ yĭp′·sĭ·lăn′·tē by outsiders) is a city in Washtenaw County in the U.S. state of Michigan. As of the 2000 census, the city population was 22,362. The city is bounded to the north by the Charter Township of Superior and on the west, south, and east by the Charter Township of Ypsilanti.

The geographic grid center of Ypsilanti is the intersection of the Huron River and Michigan Avenue, the latter of which connects downtown Detroit, Michigan with Chicago, Illinois, and is coextensive with U.S. Route 12.

On July 23, 2007 Governor Jennifer Granholm announced that Ypsilanti, along with the cities of Caro and Clio, was chosen by the Michigan State Housing Development Authority (MSHDA) to take part in the Blueprints for Michigan's Downtowns program. The award provides for an economic development consultant to assist Ypsilanti in developing a growth and job creation strategy for the downtown area.